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Osteochondrogenesis with Autologous Peripheral Blood Stem Cells for Osteochondral Lesions of the Talus: Report of Five Cases

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Osteochondrogenesis with Autologous Peripheral Blood Stem Cells for Osteochondral Lesions of the Talus: Report of Five Cases

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Research Name

Osteochondrogenesis with Autologous Peripheral Blood-Derived Cells for Osteochondral Lesions of the Talus: Report of Five Cases

Year Published

2022

Authors

Dr Khay-Yong Saw
Dr Caroline Siew-Yoke Jee
Ms Alisha Ramlan
Ms Amal Dawam
Mr Yung-Cheng Saw
Dr Soo-Fin Low

Objective

To explore the application of the K.A.R.T.® (KLSMC Articular Regeneration Technology) protocol—originally developed for the knee joint—for the treatment of osteochondral lesions of the talus (OLTs) in the ankle, using autologous peripheral blood-derived cells and hyaluronic acid, without requiring bone grafts.

Results

Five patients with chronic ankle pain due to OLTs underwent arthroscopic subchondral drilling followed by intra-articular injections of autologous peripheral blood-derived cells combined with hyaluronic acid.
The treatment protocol included initial and follow-up injections over two years.
MRI scans showed successful regeneration of both cartilage and bone in the talar dome.
Patients experienced significant improvements in pain and disability scores on the Ankle Osteoarthritis Scale (AOS), with statistical significance (p < 0.05).
No infections or adverse events were reported.
Most patients returned to normal or sporting activities post-treatment.

Conclusion

This case series demonstrates that the K.A.R.T.® approach, using autologous peripheral blood-derived cells and hyaluronic acid, may offer a promising alternative to more invasive surgical options such as bone grafting, OATS, MACI, or joint replacement. The regenerative outcomes suggest the potential to delay or avoid joint degeneration and preserve ankle function in patients with osteochondral lesions of the talus.

As mentioned in:

National Library of Medicine

KLSMC adalah rumah sakit spesialis yang berlokasi di Kuala Lumpur, Malaysia, dengan fokus utama pada ortopedi, perawatan regeneratif, dan rehabilitasi fisioterapi. Tim profesional medis kami yang berdedikasi berkomitmen untuk membantu pasien memulihkan mobilitas serta meningkatkan kualitas hidup melalui perawatan yang dipersonalisasi dan berbasis bukti ilmiah.

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