Articular Cartilage Regeneration with Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomized Controlled Trial

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Articular Cartilage Regeneration with Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomized Controlled Trial

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Contents

Research Name

Articular Cartilage Regeneration With Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomised Controlled Trial

Year Published

2013

Authors

Dr Khay-Yong Saw
Dr Adam Anz
Dr Caroline Siew-Yoke Jee
Dr Shahrin Merican
Dr Reza Ching-Soong Ng
Dr Sharifah A. Roohi
Dr Kunaseegaran Ragavanaidu

Objective

To compare the clinical, arthroscopic, and histological outcomes of cartilage repair using autologous peripheral blood-derived cells plus hyaluronic acid versus hyaluronic acid alone after subchondral drilling.

Results

Patients treated with peripheral blood-derived cells showed significantly better cartilage regeneration under arthroscopic examination and histological grading.
The regenerated cartilage in this group was hyaline-like, in contrast to fibrocartilage observed in the control group.
MRI results and clinical outcome scores also favoured the PBSC+HA group.
No adverse effects were recorded during the study.

Conclusion

This early trial provided strong evidence supporting the use of peripheral blood-derived regenerative cells as a safe and more effective biologic approach for articular cartilage repair than hyaluronic acid alone. It set the stage for subsequent larger studies validating this method.

As mentioned in:

National Library of Medicine

KLSMC is a specialist hospital based in Kuala Lumpur, Malaysia, with a strong focus on orthopaedics, regenerative treatments, and physiotherapy rehabilitation. Our dedicated team of medical professionals is committed to helping patients regain mobility and enhance their quality of life through personalised and evidence-informed care.

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