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Autologous Peripheral Blood Stem Cell Therapy for Chronic Achilles Tendinopathy: Report of Three Cases

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Autologous Peripheral Blood Stem Cell Therapy for Chronic Achilles Tendinopathy: Report of Three Cases

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Contents

Research Name

Regenerative Cell Therapy Using Peripheral Blood-Derived Cells for Chronic Achilles Tendinopathy: Report of Three Cases

Year Published

2022

Authors

Dr Khay-Yong Saw
Dr Soo-Fin Low
Ms Alisha Ramlan
Ms Amal Dawam
Mr Yung-Cheng Saw
Dr Caroline Siew-Yoke Jee

Objective

To explore the effectiveness of autologous peripheral blood-derived cells, combined with hyaluronic acid, for the repair and regeneration of chronic Achilles tendinopathy (CAT), a condition known for its poor healing and lack of curative treatments.

Results

Three patients with long-standing Achilles tendon pain (ranging from 1 to 5 years) underwent surgical intervention involving multiple needling of the tendon, followed by repeated intra-tendinous injections of peripheral blood-derived cells and hyaluronic acid.
All cases showed significant improvement in pain, tendon structure, and function, as measured by the VISA-A score (a validated assessment tool for Achilles tendinopathy).
MRI scans confirmed a reduction in inflammation and tendon thickness, showing signs of structural regeneration.
No adverse effects were reported. Two patients achieved near-complete recovery, scoring 97 and 100 on the VISA-A scale.

Conclusion

This small case series demonstrates that peripheral blood-derived regenerative cell injections, in combination with tailored physiotherapy and minimally invasive procedures, may offer a promising biologically based treatment for chronic Achilles tendinopathy. The method appears safe, effective, and sustainable over the long term. Further clinical trials are recommended to validate these early results.

As mentioned in:

National Library of Medicine

KLSMC is a specialist hospital based in Kuala Lumpur, Malaysia, with a strong focus on orthopaedics, regenerative treatments, and physiotherapy rehabilitation. Our dedicated team of medical professionals is committed to helping patients regain mobility and enhance their quality of life through personalised and evidence-informed care.

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